- A meta-analysis finds that subclinical hyperthyroidism (SH) vs no SH is associated with bone loss in women and increased hip fracture in both sexes.
Why this matters
- More than 200 million worldwide have osteoporosis, and rates are increasing.
- Findings suggest evaluation of bone mineral density (BMD) in patients with SH.
- Meta-analysis of 12 cohort studies involving 275,086 participants followed for 3 months-13 years.
- SH was defined by low or suppressed levels of thyroid-stimulating hormone with normal concentrations of free T4 and free T3.
- Funding: Science and Technology Planning Project of Guangdong Province, China; National Natural Science Foundation of China.
- SH vs no SH had no effect on lumbar spine BMD.
- SH vs no SH was associated with a reduction in femoral neck BMD in females (risk difference, −0.03; P=.03), but not males.
- SH vs no SH was associated with an increase in hip fracture in all patients (mean difference, 0.02; P=.004), and an increase in female (mean difference, 0.03; P=.008) and male subgroups (mean difference, 0.01; P<.0001>
- High heterogeneity across studies.
- Studies were observational.