Researchers have identified a number of risk factors linked to stroke mortality in patients with end-stage kidney disease (ESKD) and say these patients may benefit from targeted stroke prevention interventions.
In the largest multinational study to date examining risk factors for stroke mortality in people with ESKD, the researchers analysed data for the entire population with ESKD in Australia and New Zealand (n=60,823).
There were 941 stroke deaths and 33,377 non-stroke deaths during 381,874 person-years of follow-up.
The authors found that the risk of stroke death was higher in older patients (adjusted sub-hazard ratio [SHR] 1.92; 95% CI 1.45-2.55), females (SHR 1.41; 95% CI 1.21-1.64), people with cerebrovascular disease (SHR 2.39; 95% CI 1.99-2.87), those with ESKD caused by hypertensive/renovascular disease (SHR 1.39; 95% CI 1.09-1.78) or polycystic kidney disease (SHR 1.38; 95% CI 1.00-1.90), those with earlier year of ESKD treatment initiation (SHR 1.93; 95% CI 1.56-2.39) and among those receiving dialysis (transplant versus haemodialysis SHR 0.27; 95% CI 0.09-0.84).
Presenting the findings in the BMJ Open, the authors said more research is needed into the use and effectiveness of stroke prevention in the ESKD population.