- Serotonin-norepinephrine reuptake inhibitors (SNRIs) are effective and safe for the prevention of vestibular migraine (VM) and may be the best option for patients with comorbid psychiatric disorders.
- The study also found that SNRIs are effective as prophylaxis for migraines, confirming earlier research findings.
Why this matters
- This meta-analysis is the first to examine the efficacy of SNRIs for the treatment of VM.
- A meta-analysis of 6 randomized controlled trials involving 418 patients.
- Funding: Natural Science Foundation of Liaoning Province.
- Patients receiving SNRIs vs those receiving placebo had significantly fewer migraine days (P=.04).
- Venlafaxine vs other active drugs had a significant advantage in:
- Decreasing the vertigo severity scores (P<.0001>
- Emotional domain of dizziness handicap inventory (P=.03).
- Adverse effects: OR, 6.07 (P=.05) vs placebo; risk difference, 0.02 (P=.79) vs active drugs.
- Any reason: OR, 2.48 (P=.13) vs placebo; OR, 0.59 (P=.31) vs active drugs.
- Small number of studies included.
- Risk for bias.
Coauthored with Vijay Rathod, PhD