SARS-CoV-2 infection accounts for few pediatric admissions for ALRD

  • Melé M & al.
  • J Infect
  • 21 oct. 2020

  • de Miriam Davis, PhD
  • Clinical Essentials
El acceso al contenido completo es sólo para profesionales sanitarios registrados. El acceso al contenido completo es sólo para profesionales sanitarios registrados.

Takeaway

  • In this prospective cohort study at a Spanish hospital, only 7 of 110 pediatric admissions for acute lower respiratory disease (ALRD) were related to SARS-CoV-2 infection.
  • SARS-CoV-2 infections were more likely to be present in older children with pneumonia.

Why this matters

  • Findings help characterize epidemiological, clinical, and microbiological characteristics of pediatric admissions for ALRD (pneumonia, bronchiolitis, bronchospasm).

Study design

  • Prospective cohort study of 110 children requiring admission with ALRD during the SARS-CoV-2 pandemic.
  • Funding: Kids Corona platform (Hospital Sant Joan de Déu), Spain.

Key results

  • 7 of 110 admitted patients were SARS-CoV-2+; the rest were SARS-CoV-2.
  • Those who were SARS-CoV-2+ were more likely to be older children:
    • Median age overall: 16.9 (interquartile range: 11.7-17.7) years.
    • Median age, SARS-CoV-2 admissions: 3.5 (0.9-7.5) years.
  • In the 7 positive cases, pneumonia was the most frequent clinical diagnosis (6/7), but without bronchospasm.
  • Only 1 of 29 infants admitted was SARS-CoV-2+, and that infant had bronchiolitis.
  • No differences in symptom profiles were found between those who were SARS-CoV-2+ and SARS-CoV-2.
  • Patients who were SARS-CoV-2+ vs SARS-CoV-2 had lower values for leukocytes (P=.001), lymphocytes (P=.007), neutrophils (P=.010), and platelets (P=.012), but higher values for creatinine (P=.007).

Limitations

  • Single-center study.
  • Small number of SARS-CoV-2+ cases.
  • Observational design.