- In this prospective cohort study at a Spanish hospital, only 7 of 110 pediatric admissions for acute lower respiratory disease (ALRD) were related to SARS-CoV-2 infection.
- SARS-CoV-2 infections were more likely to be present in older children with pneumonia.
Why this matters
- Findings help characterize epidemiological, clinical, and microbiological characteristics of pediatric admissions for ALRD (pneumonia, bronchiolitis, bronchospasm).
- Prospective cohort study of 110 children requiring admission with ALRD during the SARS-CoV-2 pandemic.
- Funding: Kids Corona platform (Hospital Sant Joan de Déu), Spain.
- 7 of 110 admitted patients were SARS-CoV-2+; the rest were SARS-CoV-2−.
- Those who were SARS-CoV-2+ were more likely to be older children:
- Median age overall: 16.9 (interquartile range: 11.7-17.7) years.
- Median age, SARS-CoV-2− admissions: 3.5 (0.9-7.5) years.
- In the 7 positive cases, pneumonia was the most frequent clinical diagnosis (6/7), but without bronchospasm.
- Only 1 of 29 infants admitted was SARS-CoV-2+, and that infant had bronchiolitis.
- No differences in symptom profiles were found between those who were SARS-CoV-2+ and SARS-CoV-2−.
- Patients who were SARS-CoV-2+ vs SARS-CoV-2− had lower values for leukocytes (P=.001), lymphocytes (P=.007), neutrophils (P=.010), and platelets (P=.012), but higher values for creatinine (P=.007).
- Single-center study.
- Small number of SARS-CoV-2+ cases.
- Observational design.