Regular use of proton pump inhibitors (PPIs) is linked to a heightened risk of developing type 2 diabetes (T2D), finds research published in the journal Gut.
At enrolment and every two years after that, participants (n=204,689) aged 25-75 years provided updated information on health behaviours, medical history, newly diagnosed conditions, and whether they had used PPIs regularly (≥2 time a week) in the preceding two years.
During follow-up of 9-12 years, 10,105 participants developed T2D. The annual absolute risk of a diagnosis among regular PPI users was 7.44/1000 compared with 4.32/1000 among those who didn’t take these drugs.
After taking account of potentially confounding factors, including hypertension, hypercholesterolaemia, physical inactivity and use of other medication, those who regularly used PPIs were 24 per cent more likely to develop T2D than those who didn’t.
And the longer these drugs were taken, the greater the risk: use for 2 years was associated with a 26 per cent increased risk. The risk fell with greater duration since stopping.
“Owing to wide usage, the overall number of diabetes cases associated with PPI use could be considerable,” the researchers warn.