New findings suggest pre-eclampsia is associated with an increased risk of later dementia, and particularly vascular dementia.
Researchers examined data on almost 1.2 million women in Denmark with at least one live birth or stillbirth between 1978 and 2015, and compared the risk of dementia among those with and without a history of pre-eclampsia.
They found women with a history of pre-eclampsia had a 53 per cent increased risk of dementia overall compared with women with no history of pre-eclampsia (hazard ratio [HR] 1.53; 95% CI 1.26-1.85) and more than three times the risk of later vascular dementia (HR 3.46; 95% CI 1.97-6.10). The association for vascular dementia was stronger for late-onset disease (age ≥65 years) than for early-onset disease (age
“Our findings suggest that asking about a history of pre-eclampsia could help physicians to identify a group of women who might benefit from early attention to modifiable vascular risk factors for dementia, such as concerted efforts to reduce blood pressure and blood cholesterol concentrations,” the authors said.
The research is published in the BMJ.