Portfolio diet may be a useful add-on to statin therapy


  • Mary Corcoran
  • Univadis Medical News
El acceso al contenido completo es sólo para profesionales sanitarios registrados. El acceso al contenido completo es sólo para profesionales sanitarios registrados.

Following the ‘Portfolio dietary pattern’ could lead to clinically meaningful improvements in LDL cholesterol (LDL-C) and other established cardiometabolic risk factors along with estimated 10-year coronary heart disease (CHD) risk. That is according to a new review and meta-analysis of data on the subject published in Progress in Cardiovascular Diseases

The diet has four main components namely; 45 g/day nuts, 50 g/day plant protein, 20 g/day viscous fibre, and 2 g/day plant sterols. 

Researchers examined data from seven trials including 439 participants with hyperlipidaemia in which the Portfolio dietary pattern was given on a background of a National Cholesterol Education Program (NCEP) Step II diet. 

They found the combination of a portfolio dietary pattern and NCEP Step II diet reduced LDL-C by around 17 per cent. The diet also lowered non-HDL cholesterol, apolipoprotein B, total cholesterol, triglycerides, systolic and diastolic blood pressure, and C-reactive protein compared with an NCEP Step 2 diet alone. Estimated 10-year risk of CHD was reduced by 13 per cent. 

The authors said the findings suggest the Portfolio diet may be a useful add-on to statin therapy or statin plus ezetimibe therapy to help achieve lipid targets.