- In pediatric patients with acute myeloid leukemia (AML), shorter time to neutrophil recovery after first induction was associated with reduced risk for grade 3/4 infection and relapse.
Why this matters
- High-intensity AML treatment in children is associated with neutropenia and risk for infections.
- Study to investigate an association between neutrophil recovery time after first induction and infection and relapse in 279 pediatric patients with newly diagnosed AML.
- Patients were treated per the NOPHO-AML 2004 or DB AML-01 protocols.
- Funding: Danish Childhood Cancer Foundation; Danish Cancer Society; Novo Nordisk Foundation.
- Modest association between neutrophil recovery time after first induction and neutrophil recovery time after subsequent treatment.
- Neutrophil recovery >25 days after first induction was associated with increased risk for grade 3/4 infection during remaining treatment: HR adjusted for sex, age, and ethnicity=1.4; 95% CI, 1.1-1.8).
- In 264 patients who did not receive hematopoietic stem cell transplantation during the first remission:
- 118 experienced the first relapse.
- Neutrophil recovery >30 days after first induction was associated with increased risk for relapse (HR, 1.7; 95% CI, 1.1-2.6).
- Complete blood counts were undertaken twice a week.
- Sample size was underpowered for some analyses.