Paternal history linked to "young-onset" T2D

  • Middleton TL & al.
  • J Diabetes Complications
  • 1 dic. 2019

  • de Craig Hicks
  • Clinical Essentials
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Takeaway

  • Earlier emergence of type 2 diabetes (T2D) is associated with a paternal history of the disease.

Why this matters

  • Carefully collected family history data can further the understanding of T2D, and in time may help identify patients who stand to benefit from early, regular screening, say researchers.

Study design

  • Researchers analyzed parental history data from patients with T2D (N=11,467; maternal history only, 21.2%; paternal history only, 12.1%; both, 6.1%), comparing them by age of diagnosis.
  • Funding: None.

Key results

  • "Young-onset" patients diagnosed between 15 and years of age had the highest prevalence of any parental history of diabetes (60.7%), the highest combined maternal and paternal history (15.8%), and the smallest differential between maternal (25.1%) and paternal (19.7%) history of diabetes.
  • This group showed no significant association between parental history and cardiometabolic risk factors or diabetic complications for a median of 15.0 years after T2D diagnosis.

Limitations

  • The study was observational and single-center.
  • Patient parental histories were self-reported.