Osteoporosis linked with increased risk of dementia


  • Mary Corcoran
  • Univadis Medical News
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A new study has identified a positive association between osteoporosis and dementia, with researchers suggesting women with osteoporosis could have a 1.2 fold increase in the risk of being diagnosed with dementia, while men with osteoporosis could have a 1.3-fold increased risk. 

The study, published in the Journal of Alzheimer’s Disease , investigated the impact of osteoporosis on the risk of developing dementia in almost 60,000 patients from more than 1,200 practices in Germany. The cohort included 29,983 patients with osteoporosis and 29,983 controls.

After a follow-up period of 20 years, 20.5 per cent of women with osteoporosis and 16.4 per cent of controls had been diagnosed with dementia (P<.001 a total of per cent men previously diagnosed with osteoporosis and controls were dementia>

"The major hypothesis to explain the association between osteoporosis and dementia is that these two conditions have similar risk factors,” said co-author Dr Louis Jacob from the University of Paris V in France. "These factors include APOE4 allele of the apolipoprotein E, a major cholesterol carrier, lower vitamin K levels, vitamin D deficiency, but also androgens and oestrogens."