One in five extremely pre-term infants survive to discharge


  • Dawn O'Shea
  • Univadis Medical News
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One in five infants with birth weight (BW) less than 400 g survive to discharge, but neurodevelopmental impairment (NDI) is common in survivors, according to a study published in JAMA Pediatrics.

The retrospective multi-centre study analysed data from 205 extremely pre-term infants born between January 2008 and December 2016 with BW less than 400 g and gestational age (GA) of 22-26 weeks.

Almost 65 per cent of included infants were singletons and 178 (86.8%) were small for gestational age. Nearly half (49.3%) received active treatment at birth.

Overall, less than 13 per cent of infants survived to discharge (12.7%; 95% CI 8.5%-18.9%), increasing to 25.7 per cent (95% CI 17.6%-35.4%) for actively treated infants.

Within the subset of infants with BW less than 400 g and GA of 22-23 weeks, six of 36 actively treated infants (17%; 95% CI 6%-33%) survived to discharge.

Among infants born between 2008 and 2015, 23 of 90 actively treated infants (26%; 95% CI 17%-36%) survived to discharge. Two infants died after discharge, and two were lost to follow-up.

Nineteen of 90 actively treated infants (21%; 95% CI 13%-31%) were evaluated at 18 to 26 months’ corrected age. Moderate or severe NDI occurred in 14 of 19 infants (74%).