A new study which evaluated the mediating role of non-steroidal anti-inflammatory drug (NSAID) use in the relationship between osteoarthritis (OA) and cardiovascular disease (CVD) has found NSAID use could substantially contribute to the OA-CVD association.
The study included 7,743 OA patients and 23,229 non-OA controls from British Colombia in Canada.
It found individuals with OA had a 23 per cent higher risk of developing CVD compared to people without OA. The risk of congestive heart failure was 42 per cent higher among people with OA compared with people without OA, while the risk of ischaemic heart disease and stroke were 17 per cent and 14 per cent greater in OA patients, respectively.
The authors reported that approximately 41 per cent of the increased risk of CVD among people with OA was mediated through their NSAID use.
Writing in Arthritis & Rheumatology, the authors said the findings suggest “that a noteworthy portion of the increased risk of CVD among people with OA is mediated through their NSAIDs use". They said future research is necessary using prospective follow-up to confirm these findings.