No association between antenatal vitamin D exposure and atopic disease outcomes in childhood


  • Priscilla Lynch
  • Univadis Medical News
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There is no significant association between antenatal vitamin D exposure and atopic disease outcomes in childhood, suggests a new prospective study in Allergy.

Previous research has suggested that maternal vitamin D status may have a protective effect against offspring allergic disease.

This study investigated associations between intrauterine vitamin D status and atopic outcomes in an extensively characterised, disease-specific, maternal-infant cohort with clinically validated outcomes and longterm followup.

Circulating 25-hydroxyvitamin D (25(OH)D) was measured in maternal sera at 15 weeks gestation (n=1537) and umbilical cord blood (n=1050), and the association with specific atopic disease outcomes in offspring at two and five years was explored using multivariable logistic regression adjusted for a range of potential confounding factors.

Persistent eczema in the first two years of life was present in 5 per cent of the offspring. Food allergy at two years was confirmed in 4 per cent. The prevalence of aeroallergen sensitisation at two years was 8 per cent. At five years, asthma was reported in 15 per cent, and allergic rhinitis in 5 per cent, of the offspring.

The study found there were no significant differences in the distributions of maternal 25(OH)D at 15-weeks gestation and cord 25(OH)D concentrations between offspring with and without atopic disease.