- Roughly a fifth of patients with Down syndrome aged 40-54 years and more than half of those aged 55 years and older had dementia claims.
Why this matters
- Findings have implications for identifying prodromal presentations and planning dementia services and supports for adults.
- Among patients aged 40-54 years:
- 18.8% had a dementia claim.
- Dementia incidence was 49 cases per 1000 person-years.
- Among patients aged ≥55 years:
- 52.2% had a dementia claim.
- 32.7% had an Alzheimer’s disease claim.
- Dementia incidence was 102 cases per 1000 person-years.
- Probability of an incident dementia claim over 11 years:
- 40% for patients aged 40-54 years at baseline.
- 67% for patients aged ≥55 years at baseline.
- Prevalence of dementia:
- Similar for men and women aged
- Higher for women vs men aged 40-54 years (prevalence ratio, 1.23).
- Similar for men and women aged ≥55 years.
- Retrospective cohort study of 2968 adults aged ≥21 years with Down syndrome in Wisconsin covered by Medicaid during 2008-2018.
- Main outcome: dementia (ascertained from claims).
- Funding: National Institute of Child Health and Human Development; National Center for Advancing Translational Sciences; Agency for Health Care Research and Quality.
- Reliance on claims data.
- Unknown generalizability.