- Older adults with a history of migraine had roughly a tripling and quadrupling of the 5-year risks for all-cause dementia and for Alzheimer’s disease, respectively.
Why this matters
- These associations may have implications for migraine management, dementia screening, and intervention.
- Incidences during 5-year follow-up:
- All-cause dementia: 7.5%.
- Alzheimer’s disease: 5.1%.
- Vascular dementia: 1.9%.
- All migraineurs developing dementia were women.
- Relative to older adults without a history of migraine, those with a history of migraine had elevated risks for:
- All‐cause dementia (aOR, 2.97; 95% CI, 1.25‐6.61).
- Alzheimer’s disease (aOR, 4.22; 95% CI, 1.59‐10.42).
- No significant association seen for vascular dementia:
- Before adjustment (unadjusted OR, 1.83; 95% CI, 0.39‐8.52).
- After adjustment (aOR, 1.52; 95% CI, 0.20‐7.23).
- Canadian prospective, population‐based cohort study of 679 cognitively intact, community‐dwelling individuals aged ≥65 years (Manitoba Study of Health and Aging).
- Main outcomes: all‐cause dementia, Alzheimer’s disease, vascular dementia.
- Funding: National Health Research and Development Program of Health Canada.
- Use of a single, self-reported migraine measure that did not distinguish between migraines with and without aura.
- Exclusion of participants who died during follow-up.
- Low incidence of vascular dementia.
- Inability to assess risk according to sex.