- In patients with stage I/II cutaneous melanoma, age, primary site, and thickness are associated with lymphatic metastasis, while thickness, TERT promoter status, and BRAF mutation status are associated with hematogenous metastasis.
Why this matters
- Risk factor identification will aid follow-up and adjuvant treatment strategies.
- 9.2% of patients developed lymphatic metastasis and 9.2% developed hematogenous metastasis.
- Age >55 years (HR, 1.9; P=.01), head/neck primary (HR, 1.7; P=.04), acral primary (HR, 2.4; P=.005), Breslow thickness (HR, 5.1, P<.001 for mm hr>4.00 mm) were associated with lymphatic metastasis in multivariate analysis.
- Breslow thickness (HR, 4.2; P=.007 for 1.01-2.00 mm; HR, 13.5; P<.001 for mm>4.00 mm), TERT promoter mutation (HR, 2.9; P=.001), and BRAF mutation (HR, 1.9; P=.03) were associated with hematogenous metastasis in multivariate analysis.
- 1177 patients with stage I/II cutaneous melanoma were analyzed for metastases and associated factors.
- Funding: None disclosed.
- Retrospective study.