- Letrozole (Femara) stimulation is associated with a higher live birth rate (LBR) compared with artificial cycle in patients with PCOS undergoing frozen-thawed embryo transfer (FET).
Why this matters
- The best approach for endometrial preparation before FET is unclear and has been poorly studied in patients with PCOS.
- Letrozole-stimulated cycle FET was associated with a higher ongoing pregnancy rate (aOR, 1.24; 95% CI, 1.02-1.51) and LBR (aOR, 1.33; 95% CI, 1.09-1.61) compared with artificial-cycle FET in adjusted analysis.
- Letrozole-stimulated cycle FET was associated with a lower rate of miscarriage (aOR, 0.51; 95% CI, 0.35-0.74) compared with artificial-cycle FET in adjusted analysis.
- Endometrial thickness was greater in the letrozole group compared with the artificial-cycle group (11.91 vs 10.10 mm; P<.001 on the day of progesterone supplementation vs mm embryo transfer>
- 2664 patients with PCOS, 1571 who received letrozole-stimulated cycle FET and 1093 who received artificial-cycle FET, were analyzed for outcomes.
- Funding: National Key Research and Development Program of China, National Natural Science Foundation of China, China Postdoctoral Science Foundation.
- Retrospective study.
- Endometrial receptivity assay not performed on both groups of patients.