- A diet rich in vegetables, whole grains, and fish (a "prudent" pattern) is associated with slower progression of knee osteoarthritis (KOA).
- A diet rich in processed meats and refined grains (a "Western" pattern) is associated with more rapid disease progression.
Why this matters
- This study is among the first to evaluate dietary patterns and KOA progression.
- Prospective cohort (the Osteoarthritis Initiative; n=2757).
- Radiographic progression defined by 1 full Kellgren-Lawrence (KL) grade increase and loss in joint space width (JSW); symptomatic progression defined by an increase in or remaining in 1 of the 2 highest categories of the Western Ontario and McMaster Universities Arthritis Index (WOMAC).
- Funding: NIH; Novartis, MSD; GlaxoSmithKline; Pfizer.
- Median follow-up, 48 months.
- Increasing Western pattern score (quartile 4 vs 1) was associated with:
- Increased KL-worsening: HR, 1.30 (95% CI, 1.05-1.61);
- Increased progression to higher WOMAC score: OR, 1.39 (95% CI, 1.18-1.63); but
- No change in JSW.
- Increasing prudent pattern score (quartile 4 vs 1) was associated with:
- Decreased KL-worsening: HR, 0.79 (95% CI, 0.64-0.98);
- Decreased progression to higher WOMAC score: OR, 0.73 (95% CI, 0.62-0.86); and
- Decreased JSW loss: 0.38 vs 0.46 mm (Ptrend<.01>
- Observational design.