Inhaled loxapine reduces/avoids physical restraint in psychotic agitation | WCP


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Takeaway

  • Inhaled loxapine reduces/avoids physical restraint in psychotic agitation. 

Why this matters

  • In 16 of the agitated patients reduction of the psychomotor excitement allowed the clinicians to remove the physical restraint.  

Study design

  • Spanish investigators analyzed the efficacy and safety of loxapine inhalation powder in acutely agitated patients with schizophrenia, schizoaffective disorder, or bipolar disorder.
  • 43 patients were analyzed (male 51%), with an average age of 37.4 y, diagnosed with schizophrenia (9), schizoaffective disorder (5), or bipolar disorder (29).
  • When the patients presented an agitation episode they inhaled loxapine 9.1 mg, using the staccato system.
  • Efficacy was measured as a change from baseline in the Positive and Negative Syndrome Scale-Excited Component (PANSS-EC) and at one h after administration. 

Key results

  • A mean reduction of 8.7 points (from mean PEC score of 21.2 at baseline to 12.5 at one h after administration) was found in PANSS-EC (t test, P<.0001>
  • In 16 of the total agitated patients reduction of psychomotor excitement allowed the clinicians to remove the physical restraint.
  • In 20 patients physical restraint could be avoided during the whole treatment.
  • 6 of the patients experienced clinical improvement of the psychomotor excitement but it was not possible to remove the physical restraint.