- In women ≤40 years, infant-related risks associated with medically assisted reproduction (MAR) are not increased with higher maternal age.
Why this matters
- More than 7% births in Denmark and Belgium are babies who were conceived with MAR.
- The rate of children born after conception via MAR was 4.9%.
- Among infants resulting from MAR compared with those conceived naturally, higher incidence of:
- Low birth weight (LBW): 12.6% vs 3.4%; and
- Preterm birth: 14.2% vs 4.9%.
- Among women who conceived naturally, LBW and preterm birth risk grew with increasing maternal age:
- For age ≥40 years, predicted probability of preterm birth was 1.61 (95% CI, 0.41-2.81).
- In women who conceived with MAR, LBW and preterm risks did not increase with age up to age 40 years.
- For age ≥40 years, the predicted probability of preterm birth was 2.02 (95% CI, −4.30 to 8.33).
- Retrospective cohort study.
- Cohort was obtained from the Finnish population register.
- Children born between 1995 and 2000 were identified (n=54,623).
- Children conceived through MAR were identified from the National Prescription Register (n=2624).
- Outcomes of interest included LBW (
- Funding: European Research Council.
- Study did not distinguish among types of MAR.