- Crohn's disease (CD) and ulcerative colitis (UC) may confer a higher risk for myocardial infarction (MI) and stroke.
Why this matters
- The association between IBD and cardiovascular disease is controversial, with previous studies reporting inconsistent results.
- Researchers analyzed the health records of patients diagnosed with CD or UC (N=37,477; 56.8% men; mean age, 40.4±16.6 years), comparing them with those of age-matched control patients.
- Funding: National Research Foundation of Korea.
- CD was associated with higher MI risk (HR, 1.80; 95% CI, 1.47‐2.21), especially among:
- those aged
- women (HR, 2.18; 95% CI, 1.61‐2.94).
- Women with UC also had higher MI risk (HR, 1.33; 95% CI, 1.13‐1.56).
- Patients aged
- With CD: HR, 2.01 (95% CI, 1.11‐3.63).
- With UC: HR, 1.86 (95% CI, 1.18‐2.95).
- Researchers did not adjust for the effects of IBD medication, statins, or aspirin.
- Patients were participants in the South Korean universal health insurance system, and findings may not apply to other populations.