Herpes zoster is linked to chronic inflammatory skin disease

  • J Am Acad Dermatol

  • de Brian Richardson, PhD
  • Clinical Essentials
El acceso al contenido completo es sólo para profesionales sanitarios registrados. El acceso al contenido completo es sólo para profesionales sanitarios registrados.

Takeaway

  • Hospitalization for herpes zoster (HZ) is associated with chronic inflammatory skin diseases (CISDs), such as atopic dermatitis and psoriasis.

Why this matters

  • Few studies have evaluated the link between HZ and CISD, which share several risk factors.

Key results

  • Hospitalization for HZ was associated (ORs; 95% CIs) on multivariate analysis with: 
    • Atopic dermatitis: 3.19 (1.93-5.28).
    • Psoriasis: 1.38 (1.14-1.68).
    • Pemphigus: 4.78 (2.83-8.08).
    • Bullous pemphigoid: 1.77 (1.01-3.12).
    • Mycosis fungoides: 3.79 (2.55-5.65).
    • Dermatomyositis: 7.31 (5.27-10.12). 
    • Systemic sclerosis: 1.92 (1.47-2.53). 
    • Cutaneous lupus erythematosus: 1.94 (1.10-3.44).
    • Vitiligo: 2.00 (1.04-3.85).
    • Sarcoidosis: 1.52 (1.22-1.90).
  • Hospitalization for HZ also was associated (ORs; 95% CIs) with:
  • Age:
    • 40-59 years: 1.71 (1.61-1.82).
    • ≥60 years: 3.28 (3.09-3.49).
  • Female vs male sex: 1.31 (1.28-1.35).
  • Race/ethnicity:
    • Hispanic: 1.16 (1.12-1.21).
    • Asian/Pacific-Islander/Native-American/other: 1.22 (1.16-1.28).
  • Long-term systemic corticosteroid use: 3.05 (2.80-3.31).

Study design

  • 68,088,221 hospitalized patients from the US Nationwide Inpatient Sample were included.
  • Funding: Agency for Healthcare Research and Quality; Dermatology Foundation; NIH.

Limitations

  • Observational, cross-sectional study of large database.