New research suggests gestational diabetes mellitus is associated with incident diabetes in offspring during childhood and adolescence.
The study, published in the Canadian Medical Association Journal , included 73,180 mothers from Quebec (1990-2012) and compared data on randomly selected singleton births from mothers with gestational diabetes with births from mothers without gestational diabetes.
Three hundred and fifty-nine (0.49%) offspring developed diabetes. The study found the incidence of diabetes per 10,000 person-years was 4.5 in children born to mothers with gestational diabetes and 2.4 in mothers without. After adjustments, gestational diabetes mellitus was associated with diabetes in offspring from birth to age 22 years (adjusted hazard ratio [HR] 1.77; 95% CI 1.41-2.22).
The authors said the findings have the potential to “stimulate clinicians” to consider the possibility of diabetes if offspring of a mother with gestational diabetes mellitus develop signs and symptoms such as polyuria, polydipsia, weight loss or fatigue. “Future studies are needed to examine longer-term outcomes in patients with paediatric diabetes with a history of maternal gestational diabetes mellitus, to ascertain how they compare with other patients with childhood- or youth-onset diabetes, in terms of disease severity and outcomes,” they added.