- Women with acute transient or mild neurologic symptoms were more likely than men to receive a diagnosis of stroke mimic, but had similar subsequent stroke risk.
Why this matters
- Little is known about sex differences in minor ischemic cerebrovascular events.
- Relative to men, women:
- Less likely to receive cerebral ischemia diagnosis (67.8% vs 76.8%; adjusted risk ratio [aRR], 0.88; 95% CI, 0.82-0.95),
- Similarly likely to have 90-day stroke recurrence (aRR, 0.90; 95% CI, 0.48-1.66), and
- Similarly likely to have 90-day composite outcome (stroke, myocardial infarction, death; aRR, 0.86; 95% CI, 0.54-1.32).
- Sexes not significantly different on presenting symptoms.
- When patients with no focal neurologic symptoms were comparator, diagnosis of cerebral ischemia more likely for those with:
- Both focal, nonfocal symptoms (aRR, 1.28; 95% CI, 1.15-1.39).
- Focal symptoms only (aRR, 1.45; 95% CI, 1.34-1.53).
- Canadian prospective cohort study, 1648 patients with acute transient or minor neurologic symptoms suspected of having either:
- Minor ischemic cerebrovascular event (transient ischemic attack, minor stroke).
- Stroke mimic (syncope, seizure, migraine, peripheral neuropathy).
- Main outcome: clinical diagnosis (cerebral ischemia vs stroke mimic).
- Funding: Genome British Columbia; others.
- Patients recruited from academic emergency departments, referred to neurology service.
- Care after initial diagnosis not collected.