Fluctuations in metabolic parameters could increase cardiovascular risk in healthy people


  • Mary Corcoran
  • Univadis Medical News
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Fluctuations in fasting blood glucose and total cholesterol levels, systolic blood pressure, and body mass index (BMI) could be linked with a higher risk for all-cause mortality, myocardial infarction (MI) and stroke, suggests new research. 

As part of a new study, published in Circulation, researchers examined data on 6,748,773 people from the Korean National Health Insurance System to assess whether variability in these parameters impacted on outcomes in the general population. All participants were free of diabetes, hypertension or dyslipidaemia and underwent three or more health examinations during 2005-2012 and were followed to the end of 2015. 

Compared to the group with low variability for all four parameters, the group with high variability for all four parameters had a significantly higher risk for all-cause mortality (HR 2.27; 95% CI 2.13-2.42), MI (HR 1.43; 95% CI 1.25-1.64) and stroke (HR 1.41; 95% CI 1.25–1.60). The risk of outcomes increased significantly with the number of high-variability metabolic parameters. 

The authors said the findings suggest that variability in metabolic parameters may be prognostic surrogate markers for predicting mortality and cardiovascular outcomes.