Excision can improve long-term QoL in early head/neck melanoma

  • JAMA Dermatol

  • de Brian Richardson, PhD
  • Univadis Clinical Summaries
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Takeaway

  • A prospective study suggests that surgical excision of Tis and T1a melanoma of the head and neck is associated with improved health-related QoL (HRQoL).

Why this matters

  • Surgical excision is standard treatment for Tis/T1a melanomas of the head and neck, but the effects on QoL were unknown.

Key results

  • Female patients had worse HRQoL at baseline compared with males (14.2 vs 7.0 [P=.03] on Skindex-16 Score; 57.2 vs 73.5 [P=.008] on Skin Cancer Index [SCI] Score).
  • Patients
  • Total Skindex-16 scores were worse at the perioperative time point vs baseline (26.3 vs 14.6; P<.001 but had improved at the postoperative time point vs>
  • Total SCI scores improved at 6 months vs baseline (81.5 vs 68.8; P<.001 and year vs baseline>

Study design

  • 56 patients with Tis/T1a melanoma of the head and neck who underwent staged excision were analyzed for HRQoL at baseline, perioperatively, at 6 months, and at 1 year.
  • Funding: American Society of Dermatologic Society; National Cancer Institute/NIH.

Limitations

  • Small patient sample size.