The association between physical activity (PA) and risk for Parkinson’s disease (PD) is increasingly recognised and now new research has demonstrated an inverse dose-response association between PA and PD risk among men.
As part of a new systematic review and meta-analysis, researchers examined data from eight prospective studies with 544,336 participants, including 2,192 patients with PD, to quantify the dose-response association between PA and the risk of developing PD.
They identified a significantly reduced risk of PD with the highest levels of either total PA (relative risk [RR] 0.79; 95% CI 0.68-0.91) or moderate to vigorous PA (RR 0.71; 95% CI 0.58-0.87), with stronger associations among men than among women. Light PA was not associated with PD risk (RR 0.86; 95% CI 0.60-1.23).
For each 10 metabolic equivalent of task-hours/week increase in the total of moderate to vigorous PA, the risk of PD among men decreased by 10 per cent and 17 per cent respectively. The authors did not identify a linear dose-response association between PA and PD risk among women.
Presenting the research in JAMA Network Open, the authors said the findings may help guide physicians in making recommendations with respect to the degree of PA that can help reduce the risk of PD.