- Severe herpes zoster (HZ) requiring hospitalization may confer 10-fold higher risk for cerebral vasculopathy, 7-fold higher risk for nonarrhythmic myocardiopathy, and 5-fold higher risk for cardiovascular diseases (CVDs), excluding hypertension.
Why this matters
- In light of significant effect of severe HZ on chronic diseases, consider vaccination in elderly, high-risk patients.
- 437 hospitalized patients with HZ, 2622 non-HZ controls.
- Hospitalization rates increased with age to >50 cases/100,000 residents in adults age ≥84 years.
- Hospital length of stay was higher with HZ vs without (median, 9 vs 7 days; P<.001>
- HZ cohort had higher prevalences vs non-HZ of:
- Prior transplantation: 1.83% vs 0.34% (P<.001>
- HIV positivity: 1.37% vs 0.04% (P<.001>
- Autoimmune conditions: 4.12% vs 2.33% (P=.029); and
- Rare diseases: 1.14% vs 0.31% (P=.013).
- CVD: 11.17% vs 2.09% (P<.001>
- Cerebral vasculopathy: 6.13% vs 0.60% (P<.001>
- Nonarrhythmic myocardiopathy: 4.31% vs 0.59% (P=.002); and
- Neuropathy: 2.62% vs 0.56% (P=.033).
- Retrospective cohort assessing effect of severe HZ (requiring hospitalization) on clinical disease progression, prevalence 6 months prehospitalization, and incidence at 6 months posthospitalization in older adults vs matched non-HZ controls.
- Funding: None disclosed.
- Miscoding, data reporting errors possible.
- No mild cases, less frail patients.
- Data sensitivity low.