- Avoiding infant exposure to cow’s milk formula in the first 3 days of life is linked to reduced risk for sensitization and allergy to cow’s milk in children with increased risk for atopy.
Why this matters
- These authors say that their findings suggest that this allergy and sensitization are largely avoidable with this approach.
- Editorial: the results add valuable information to aid in identifying the right window of avoidance.
- In avoidance group, 16.8% had sensitization by their second birthday compared with 32.2% in the nonavoidance group: risk ratio (RR), 0.52; 95% CI, 0.34-0.81.
- Immediate food allergy at the second birthday was also lower in the avoidance group (2.6%) compared with the nonavoidance group (13.2%): RR, 0.20; 95% CI, 0.07-0.57.
- Anaphylactic allergy was also lower at 0.7% with avoidance group vs 8.6% with nonavoidance group: RR, 0.08; 95% CI, 0.01-0.58.
- Randomized, nonblinded clinical trial in Japan, with 312 infants randomly allocated 1:1 to breastfeeding with cow’s milk formula supplementation or with elemental formula supplementation.
- Primary outcome: sensitization by the second birthday.
- Funding: Ministry of Education, Culture, Sports, Science, and Technology of Japan; others.
- Not double-blinded, small numbers with allergy, sensitization.