- Abnormal conventional coagulation parameters, e.g., elevated D-dimer and fibrin degradation product (FDP) levels, are associated with poorer outcomes in novel coronavirus pneumonia (NCP).
- Disseminated intravascular coagulation (DIC) ≥5 points in later-stage illness is associated with mortality.
Why this matters
- Coagulation testing may serve to guide NCP management.
- 183 patients with NCP.
- Mean age, disease onset: 54.1 (range, 14-94) years.
- 41.0% (75) had chronic diseases.
- All patients received antiviral, supportive therapies.
- 11.5% (21) died.
- 71.4% (15) nonsurvivors vs 0.6% (1) survivors matched International Society on Thrombosis and Haemostasis diagnostic criteria for overt-DIC.
- Median time, admission-DIC: 4 (range, 1-12) days.
- At admission, nonsurvivors had significantly higher:
- D-dimer (µg/mL): 2.12 (0.77-5.27) vs 0.61 (0.35-1.29) survivors.
- FDP (µg/mL): 7.6 (4.0-23.4) vs 4.0 (4.0-4.9) survivors.
- Prothrombin time (PT, seconds): 15.5 (14.4-16.3) vs 13.6 (13.0-14.3) survivors, respectively; P<.001 all.>
- Late hospitalization, fibrinogen, antithrombin levels significantly lower in nonsurvivors, suggesting link between conventional coagulation parameters and prognosis during disease course.
- Retrospective analysis of coagulation parameters in consecutive NCP cases, outcomes, in patients from Wuhan, China hospitalized with confirmed infections, January 1-February 3, 2020.
- Funding: None disclosed.
- Single center, small patient numbers.
- Limited generalizability.