Takeaway
- Certain UK population subgroups are at a significantly increased risk for elevated depressive symptoms during the current COVID-19 pandemic.
Why this matters
- Identify at-risk patients who might benefit from targeted mental health support and services.
- Consider evidence-based antidepressant strategies (e.g., behavioral interventions, drugs) to alleviate symptoms.
Key results
- 51,417 participants; mean age, 48.8 years; 12.0% (6145) Black, Asian, minority/racial communities.
- 33.3% comprised lowest socioeconomic stratum.
- 38.2% had a preexisting physical condition, 19.9% ≥1 mental health condition, 30.5% moderate or severe depression symptoms, 11.3% experienced psychological/physical abuse.
- 3 distinct depressive symptom trajectories observed: 60.0% class 1 (low), 29.0% class 2 (moderate), 11.0% class 3 (severe).
- Factors associated (ORs) with a higher likelihood for COVID-related:
- Moderate depressive symptoms:
- Prior abuse: 5.34 (P<.001>
- Low social support: 4.71 (P<.001>
- Severe vs moderate symptoms:
- Prior abuse: 13.16 (P<.001>
- Low social support: 12.72 (P<.001>
- Essential workers less likely to experience severe depressive symptoms: 0.66 (P<.001>
- Moderate depressive symptoms:
Study design
- Prospective cohort analysis of UK adults participating in an ongoing panel study to assess severity/levels of depressive symptoms among high-risk persons during the COVID-19 pandemic.
- Funding: Nuffield Foundation; others.
Limitations
- Limited generalizability.
- Self-report bias.
- Missing confounders.
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