Cochrane review: dieting may reduce psoriasis in obese patients

  • Ko SH & al.
  • Cochrane Database Syst Rev
  • 16 jul. 2019

  • de Brian Richardson, PhD
  • Clinical Essentials
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Takeaway

  • Dietary intervention may reduce psoriasis severity and improve QoL in obese individuals, according to a Cochrane systematic review and meta-analysis.

Why this matters

  • Psoriasis has no cure but is associated with metabolic and cardiovascular comorbidities that lifestyle change may modify.

Key results

  • Dietary intervention (strict caloric restriction) was associated with ≥75% improvement in Psoriasis Area and Severity Index (PASI 75; risk ratio [RR], 1.66; 95% CI, 1.07-2.58, low-quality evidence) as well as greater improvement in dermatologic QoL index score (mean difference [MD], −12.20, 95% CI, −13.92 to −10.48, moderate-quality evidence) and reduced body mass index (MD, −4.65 kg/m2; 95% CI, −5.93 to −3.36 kg/m2, moderate-quality evidence) compared with usual care in obese patients.
  • Combined dietary intervention/exercise was nonsignificantly associated with PASI 75 (RR, 1.28; 95% CI, 0.83-1.98; moderate-quality evidence) but significantly reduced BMI (median change, −1.10 kg/m2, P=.002; moderate-quality evidence) compared with information only in obese patients.

Study design

  • 10 randomized controlled trials (n=1163 participants) were included in the meta-analysis.
  • Funding: National Institute for Health Research via Cochrane Infrastructure funding to Cochrane Skin.

Limitations

  • No high-quality evidence for outcomes.