- Inhaled hypertonic saline for bronchiectasis (permanent dilation of the bronchi causing chronic cough, mucus accumulation, recurrent infections, and decreased lung function) is no more effective than 0.9% isotonic saline, a meta-analysis finds.
Why this matters
- Past results have been conflicting, and best practice has not been established.
- Meta-analysis of 4 randomized controlled trials (N=100).
- Funding: None disclosed.
- Compared with 0.9% isotonic saline, inhaled hypertonic saline did not differ in effectiveness for:
- FEV1: P=.18.
- FVC: P=.30.
- Sputum expectorated: P=.99.
- Leicester cough questionnaire score: P=.68.
- Small sample sizes.