- Anxiety symptoms independently boost progression of prediabetes to type 2 diabetes (T2D).
- Consider screening for anxiety among people with prediabetes.
Why this matters
- Identifying predictors of progression from prediabetes to T2D can facilitate reducing T2D incidence.
- Study of 1708 participants ages 31-81 years from population-based Cooperative Health Research in the Region of Augsburg F4 and its follow-up, including 14% with prediabetes and 7% with anxiety symptoms at baseline.
- Prediabetes was defined as impaired fasting glucose and/or impaired glucose tolerance, and anxiety status was measured by generalized anxiety disorder-7 questionnaire.
- Funding: German Federal Ministry of Education and Research.
- After mean 6.5 years of follow-up, 7% were diagnosed with T2D.
- Of those, 69% had baseline prediabetes, giving a 31% progression rate (~5% per year).
- By contrast, 12% with anxiety developed T2D at follow-up.
- Participants with prediabetes (OR, 10.76; P<.001 or high anxiety experienced increased odds of t2d after adjustments for age sex smoking alcohol consumption physical activity obesity hypertension and dyslipidemia.>
- Compared with those without prediabetes or anxiety, those with both had substantially higher odds of developing T2D (OR, 20.90; P<.001>
- A relevant proportion of participants had developed T2D before being lost to follow-up.
- Wide confidence intervals.