Anxiety raises risk of progression from prediabetes to T2D

  • Jiang L & al.
  • Diabet Med
  • 14 ene. 2020

  • de Miriam Tucker
  • Clinical Essentials
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Takeaway

  • Anxiety symptoms independently boost progression of prediabetes to type 2 diabetes (T2D).
  • Consider screening for anxiety among people with prediabetes.

Why this matters

  • Identifying predictors of progression from prediabetes to T2D can facilitate reducing T2D incidence.

Study design

  • Study of 1708 participants ages 31-81 years from population-based Cooperative Health Research in the Region of Augsburg F4 and its follow-up, including 14% with prediabetes and 7% with anxiety symptoms at baseline.
  • Prediabetes was defined as impaired fasting glucose and/or impaired glucose tolerance, and anxiety status was measured by generalized anxiety disorder-7 questionnaire.
  • Funding: German Federal Ministry of Education and Research.

Key results

  • After mean 6.5 years of follow-up, 7% were diagnosed with T2D.
  • Of those, 69% had baseline prediabetes, giving a 31% progression rate (~5% per year).
  • By contrast, 12% with anxiety developed T2D at follow-up.
  • Participants with prediabetes (OR, 10.76; P<.001 or high anxiety experienced increased odds of t2d after adjustments for age sex smoking alcohol consumption physical activity obesity hypertension and dyslipidemia.>
  • Compared with those without prediabetes or anxiety, those with both had substantially higher odds of developing T2D (OR, 20.90; P<.001>

Limitations

  • A relevant proportion of participants had developed T2D before being lost to follow-up.
  • Wide confidence intervals.