A new study that compared the excess risks of dying from or developing cardiovascular disease (CVD) in people diagnosed with type 2 diabetes (T2D) has found those diagnosed before 40 years of age have the greatest excess risk for CVD.
Using data from the Swedish National Diabetes Registry, researchers followed 318,083 individuals with T2D and 1,575,108 matched controls from 1998 to 2013 for CVD outcomes and to 2014 for mortality.
The median follow-up was 2.5 years. The study found T2D patients diagnosed before 40 years or less had the highest excess risk for most outcomes relative to controls with adjusted HR of 2.05 for total mortality, 2.72 for CV-related mortality, 1.95 for non-CV mortality, 4.77 for heart failure and 4.33 for coronary heart disease. All the risks attenuated progressively with each increasing decade at diagnostic age.
Reporting the results in Circulation, the authors said the findings suggest risk factor treatment target recommendations may need to be more aggressive in people developing diabetes at younger ages, while many older people newly diagnosed with T2D may not require aggressive management.