12.3% of patients with epilepsy developed osteoporosis | AES


  • Resúmenes de congresos
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Takeaway

  • Despite routine screening for bone mineral density loss, 12.3% of patients with epilepsy developed osteoporosis (femoral neck) and 13.6% suffered new major osteoporotic fractures.

Why this matters

  • Patients with epilepsy are at high risk for falls and trauma.

Study design

  • Investigators at Montefiore Medical Center in New York analyzed data from patients who had 2 dual-energy absorptiometry (DXA) scans that were performed at least 5 years apart.
  • Additional information was gathered for each patient through chart review, and included medical history, T-scores from DXA scans, antiseizure medications (AEDs) used, and bone loss treatment.

Key results

  • 81 patients met inclusion criteria: 44 female (54.3%), median age at second DXA scan 52 years.
  • 45 patients (55.6%) reported a lower T-score at the femoral neck at their second DXA scan than at their initial one.
  • Based on WHO criteria, 24 patients (29.6%) had osteopenia at the femoral neck and 14 (17.3%) had osteoporosis at this site at the time of their second DXA scan.
  • 11 patients (13.6%) sustained a major osteoporotic fracture after their first DXA scan.
  • Of these patients with new fractures, 9 (81.8%) took AEDs known to be associated with bone loss; 8 (72.7%) took treatment to prevent bone loss.